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Introduction

Adipotide is a peptide that has garnered interest in the scientific community as a tool for studying the regulation of adiposity and metabolic health. This article aims to provide a comprehensive overview of Adipotide, including its discovery, mechanisms of action, and potential applications in research.

What is Adipotide?

Adipotide is a 12-amino acid peptide that was first identified by scientists at The Scripps Research Institute in 2005. It is derived from the protein angiotensin and has been shown to selectively target and kill adipocytes, or fat cells, in vitro and in vivo.

IGF-1 LR3 is a derivative of IGF-1. Due to its structural adjustment, IGF-1 LR3 has a much longer half-life and results may persist in the bloodstream for up to 120 times longer. The half-life of IGF-1 LR3 is about 20 – 30 hours, and therefore enhance the growth amount of muscle for a whole day. It is more potent than the regular base IGF-1. 

Adipotide Mechanism of Action

The exact mechanisms by which Adipotide targets and kills adipocytes are not fully understood. However, it has been suggested that the peptide binds to blood vessels surrounding adipose tissue and induces apoptosis, or programmed cell death, in adipocytes through a process known as vascular shutdown.

What are the benefits of Adipotide?

Adipotide Peptide for Weight Loss: Animal Study Results

Adipotide peptide is a promising weight loss treatment that was studied in an animal study conducted by Dr. Arap and Dr. Pasqualini. The study involved eight obese rhesus monkeys who were fed a high-fat diet and were treated with Adipotide through daily injections for 28 days.

The results showed that the obese monkeys lost an average of 11% of their body weight, and their body fat decreased by an average of 27%. Adipotide induced apoptosis in fat cells, leading to weight loss and improved metabolic health in the monkeys.

The study suggests that Adipotide has the potential to be a non-invasive and targeted weight loss treatment for individuals with severe obesity, but further studies are necessary to determine its safety and efficacy in humans.

You can read more about the study here.

Assessing the Efficacy of Interventions

Adipotide can also be used to assess the efficacy of interventions aimed at reducing adipocyte number and/or improving metabolic health. For example, researchers can use the peptide to monitor changes in adipocyte number following treatments such as weight loss interventions, pharmacological therapies, or bariatric surgery.

Adipotide: Conclusion 

In conclusion, Adipotide is a peptide that has generated significant interest in the scientific community as a tool for studying the regulation of adiposity and metabolic health. Through its ability to selectively target and kill adipocytes, Adipotide provides a unique opportunity to investigate the relationship between adipocyte number and metabolic function, as well as to assess the efficacy of interventions aimed at reducing adipocyte number and/or improving metabolic health. However, further research is needed to fully understand the mechanisms by which Adipotide induces adipocyte death, as well as to address the limitations and challenges associated with its use.